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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Polymer-drug conjugates ： ウィキペディア英語版 Polymer-drug conjugates Polymer drug conjugates are products of Nano-medicine enrolled in cancer diagnosis and treatment. There are more than 10 anticancer conjugates in clinical development. Polymer-drug conjugates are drug molecules held up in polymer molecules. The polymer molecules are used as the delivery system for the drugs and have shown very promising results. Polymer drugs have passed multidrug resistance (MDR) testing and hence may become a viable treatment of endocrine-related cancers. A cocktail of pendant drugs could be delivered by water-soluble polymer platforms. The physical and chemical properties of the polymers used in polymer-drug conjugates are specially synthesized to flow through the kidneys and liver without getting filtered out, allowing the drugs to be used more effectively. Traditional polymers used in polymer-drug conjugates get worn-down through enzymes and acidity. Polymers are now being synthesized to be sensitive to specific enzymes that are very apparent with diseased tissue. The drugs remain attached to the polymer and are not activated until the enzymes associated with the diseased tissue are present. This process significantly minimizes damage to healthy tissue.〔Bertrand, Nicolas, and Jean-Christope Leroux. "The Journey of a Drug-carrier in the Body: An Anatomo-physiological Perspective." ScienceDirect.com. Institute of Pharmaceutical Sciences, n.d. Web. 12 Dec. 2012.〕〔Chau, Ying. "Targeted Drug Delivery by Novel Polymer-drug Conjugates Containing Linkers Cleavable by Disease-associated Enzymes." DSpace@MIT :. Massachusetts Institute of Technology, 2005. Web. 12 Dec. 2012.〕 ==Method of delivery== Most typical deliver of drugs is through the mouth, skin, transmucosal and inhalation. Drug polymer conjugate follow these to some degree, but they are usually administered through shots. Many enzymes in the body decompose the drug if the drug is taken by other means. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Polymer-drug conjugates」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.